Only Starting Players
| Position | Name | Number | Notable Statistics |
|---|---|---|---|
| QB | Mitchell Trubisky | 10 | 16 Touchdowns |
| RB | David Montgomery | 32 | 1070 Yards |
| WR | Allen Robinson II | 12 | 102 Receptions |
| WR | Anthony Miller | 17 | 485 Yards |
| WR | Darnell Mooney | 11 | 61 Receptions |
| TE | Jimmy Graham | 80 | 8 Touchdowns |
| TE | Cole Kmet | 85 | 2 Touchdowns |
| RT | Germain Ifedi | 74 | N/A |
| RG | Alex Bars | 64 | N/A |
| C | Sam Mustipher | 67 | N/A |
| LG | Cody Whitehair | 65 | N/A |
| LT | Charles Leno Jr. | 72 | N/A |
| DT | Akiem Hicks | 96 | 3.5 Sacks |
| NT | Bilal Nichols | 98 | 5 Sacks |
| DE | Brent Urban | 92 | 2.5 Sacks |
| OLB | Khalil Mack | 52 | 9 Sacks |
| ILB | Roquan Smith | 58 | 2 Interceptions |
| ILB | Danny Trevathan | 59 | 67 Tackles |
| OLB | Robert Quinn | 94 | 3 Forced Fumbles |
| CB | Kyle Fuller | 23 | 1 Interception |
| S | Tashuan Gipson Sr. | 38 | 2 Interceptions |
| S | Eddie Jackson | 39 | 3 Forced Fumbles |
| CB | Jaylon Johnson | 33 | 34 Tackles |
| P | Pat O'Donnell | 16 | 64 Punts |
| K | Cairo Santos | 2 | 30 Field Goals |